Macau Center for Mass Spectrometry and Nuclear Magnetic Resonance Analysis –Analytical Platform
1290 Ultra High Performance Liquid Chromatography – 6230 Time-of-Flight Mass Spectrometer (Agilent)
The combination of Agilent 1290 Ultra High Performance Liquid Chromatography and 6230 Time-of-Flight Mass Spectrometer is noted for its high resolution, mass accuracy and sensitivity.
UHPLC can withstand liquid pressure up to 1200 bar, capable of using a wide variety of chromatographic columns. Highly efficient separation is achieved when using column with particle size less than 2 m.
Sensitivity up to femtomole level.
Mass accuracy up to 1 ppm, providing highly confident analytical result.
lResolution > 20,000
lWide mass range with maximum at m/z 20,000
lMaximum 5-order dynamic range
Suitable for qualitative and quantitative analysis of pharmaceutical/biomedical, clinical, food and biological sample, including:
lTraditional Chinese Medicine (TCM) component.
lDrug contaminant and metabolite identification and qualitative analysis.
lTCM and metabolite identification and qualitative analysis in biological samples.
lEndogenous biomolecules or biomarkers analysis.
lProteomics and metabolomics analysis.
lTCM pesticide contamination analysis.
Macau Centerfor Mass Spectrometry and Nuclear Magnetic Resonance Analysis – Analytical Platform
1290 Ultra High Performance Liquid Chromatography – 6460 Triple Quadrupole Mass Spectrometer.
Hyphenated 1290 Ultra High Performance Liquid Chromatography – 6460 Triple Quadrupole Mass Spectrometer. The system can rapidly perform qualitative and quantitative analysis of multiple chemicaltargets in a complex sample.
The UHPLC 1290 can withstand 1200 bar pressure, with maximum flow rate at 5 ml/minutes. The system is capable of using a wide variety of chromatographic columns. Highly efficient separation is achieved when using column with particle size less than 2 m.
lAutomatic optimization of experiment with MassHunterMSOptimizer software.
l6460 Triple Q-MS has high sensitivity (S/N > 2,000) and mass range (3,000 amu) at MRM mode. The system can quantitate multiple chemicals at higher sensitivity and in shorter time period.
The system can be used for the quantitative research of chemicals in different areas, including,
lTCM bioactive or cytotoxic component analysis.
lTrace pesticide detection.
lNovel drugs development.
Macau Center for Mass Spectrometry and Nuclear Magnetic Resonance Analysis – Analytical Platform
1290 Ultra High Performance Liquid Chromatography – 6490 Triple Quadrupole Mass Spectrometer.
Hyphenated 1290 Ultra High Performance Liquid Chromatography – 6490 Triple Quadrupole Mass Spectrometer. The system is characterized by its efficiency in separation and extreme sensitivity.
The UHPLC 1290 can withstand 1200 bar pressure, with maximum flow rate at 5 ml/minutes. The system is capable of using a wide variety of chromatographic columns. Highly efficient separation is achieved when using column with particle size less than 2 m.
The 6490 Triple Q-MS utilized the latest ESI technology and ion focusing, achieving a high sensitivityup to zeptomole level.
l5-order dynamic range.
lHigh-throughput MRM analysis, capable of monitoring up to hundreds ions
lDynamic MRM mode, providing faster and more sensitive chemical analysis.
lAutomatic optimization of experiment with MassHunterMSOptimizer software.
The system can be used for pharmaceutical, biomedical, clinical, food safety, environmental safety, proteomic and peptidomic analysis. Including,
lTCM and trace metabolite analysis in biological samples
lEndogenous small biomolecule qualitative analysis.
lProtein and peptide analysis.
lTrace pesticide monitoring
Macau Center for Mass Spectrometry and Nuclear Magnetic Resonance Analysis – Analytical Platform
2D-nanoLC chip with 6550 iFunnel Q-TOF MS system (Agilent)
The system is based on the latest nanoLC chip and nanoSpray LC/MS technology. The 2D-nanoLC chip is hyphenated with high performance Agilent 6550 Q-TOF MS system to provide high efficiency separation, with high sensitivity and high mass accuracy MS analysis.
lThe unique electronic flow control (EFC) system provides a steady and precise flow gradient for the chromatographic column.
lUtilization of the latest iFunnel ESI as the ion source.
lMass resolution up to 40,000, providing a more accurate molecular weight determination.
lSensitivity up to femtogram level.
l5-order dynamic range.
lData collection rate up to 50 spectra per second.
Application:
lTCM trace component analysis and identification.
lMetabolite analysis.
lProteomics, metabolomics and glycomics analysis.
lFood safety.
